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What does ***they*** refer to?

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Lazypierrot - 30 Dec 2008 17:43 GMT
Hello!  Would someone please help me interprete the last sentence of
the following passage.  I suppose that ***they*** in the last sentence
refers to “Mistakes”, not “those manipulations.”   I wonder if I am
right or wrong, and why.

Unexpected, negative side effects are typical, not just of genetic
engineering, but of all technologies emerging from the objective
scientific approach. The difference between genetic engineering and
other technologies is the duration of negative effects. Although many
of the earlier technological impacts, such as nuclear and chemical
pollution, seem long-term from the perspective of the human time
scale, on geological and ecological time scales they are relatively
temporary. When we terminate the activities causing chemical and
nuclear pollution, mechanisms come into play that, in time, restore
the ecosystem.
 In contrast, germ-line genetic manipulations alter the reproductive
cells of the organism. As a consequence, those alterations will be
passed on to all subsequent generations. Mistakes made during those
manipulations and harmful side effects that ***they*** cause will not
disappear with time, but will be perpetuated.

I appreciate your help indeed.

LP
HVS - 30 Dec 2008 17:55 GMT
On 30 Dec 2008, Lazypierrot wrote

> Hello!  Would someone please help me interprete the last
> sentence of the following passage.  I suppose that ***they*** in
[quoted text clipped - 20 lines]
>
> I appreciate your help indeed.

I read "they" as referring to the whole of the phrase "Mistakes made
during those manipulations":

"Mistakes made during those manipulations and harmful side effects
that [the mistakes made during the manipulations] cause..."
tony cooper - 30 Dec 2008 17:59 GMT
>Hello!  Would someone please help me interprete the last sentence of
>the following passage.  I suppose that ***they*** in the last sentence
[quoted text clipped - 8 lines]
>
>I appreciate your help indeed.

"They" are the harmful side effects that mistakes cause.  

It would be a little clearer adding "the" to the sentence: Mistakes
made during those manipulations and the harmful side effects that they
cause will not disappear with time, but will be perpetuated.

The sentence is OK as is, but readers tend to get lost in long
sentences.  To prevent this, make it two sentences:  Mistakes made
during those manipulations will cause harmful side effects.  The
harmful side effects will not disappear over time and will be
perpetuated.

Signature

Tony Cooper - Orlando, Florida

HVS - 30 Dec 2008 18:08 GMT
On 30 Dec 2008, tony cooper wrote

>> Hello!  Would someone please help me interprete the last
>> sentence of the following passage.  I suppose that ***they***
[quoted text clipped - 11 lines]
>
> "They" are the harmful side effects that mistakes cause.  

I don't understand that at all.

Adding in your "the", the sentence is structured as "A and the B
that they cause".  "They" can't refer to "B", as "B" is what
"they" cause.

> It would be a little clearer adding "the" to the sentence:
> Mistakes made during those manipulations and the harmful side
[quoted text clipped - 6 lines]
>  The harmful side effects will not disappear over time and will
> be perpetuated.

Signature

Cheers, Harvey
CanEng and BrEng, indiscriminately mixed

Lazypierrot - 30 Dec 2008 18:22 GMT
> On 30 Dec 2008, tony cooper wrote
>
[quoted text clipped - 36 lines]
>
> - 引用テキストを表示 -

Thanks everyone!  BTW, it does not seem that ***they***  refers to
"those manipulations."  Would it be illogical to interpret in that
way?

LP
Cece - 30 Dec 2008 18:45 GMT
> > On 30 Dec 2008, tony cooper wrote
>
[quoted text clipped - 44 lines]
>
> - Show quoted text -

On my first reading, I understood "they" to refer to the manipulations
that cause harmful side effects.  It doesn't take mistakes to cause
harmful side effects; side effects are effects other than those
intended.  Some are harmful; some are helpful.  Aspirin, for instance,
has several effects: it relieves pain, which was the original intent;
it also has effects on the cardiovascular system, which can be good or
bad, depending on if the patient needs thinner blood or definitely
does not.
Leslie Danks - 30 Dec 2008 19:23 GMT
[...]

> Aspirin, for instance,
> has several effects: it relieves pain, which was the original intent;
> it also has effects on the cardiovascular system, which can be good or
> bad, depending on if the patient needs thinner blood or definitely
> does not.

Just a point of usage: Aspirin does not make the blood "thinner" (although
this expression is frequently used), but inhibits clotting and thus reduces
the risk of thrombosis.

Signature

Les (BrE)

tony cooper - 30 Dec 2008 20:33 GMT
>> On 30 Dec 2008, tony cooper wrote
>>
[quoted text clipped - 40 lines]
>"those manipulations."  Would it be illogical to interpret in that
>way?

In a way, the "they" refers to "those manipulations", but more
directly the "they" refers to the mistakes made in those
manipulations.  The manipulations would not have caused harmful side
effects had it not been for the mistakes.  

Signature

Tony Cooper - Orlando, Florida

tony cooper - 30 Dec 2008 20:30 GMT
>On 30 Dec 2008, tony cooper wrote
>
[quoted text clipped - 19 lines]
>that they cause".  "They" can't refer to "B", as "B" is what
>"they" cause.

I'm reading the sentence holistically.  The "they" can't refer to the
mistakes because the mistakes have already been made and there would
be no point in stating that they will not disappear over time.  The
results of the mistakes - the side effects - are ongoing and there is
a point to saying they will not disappear over time because some side
effects do disappear over time.
 
I don't follow the "A" and "B" stuff, but working with actual words
it's clear to me that the mistakes cause side effects, and these
particular side effects don't disappear later.  

>> It would be a little clearer adding "the" to the sentence:
>> Mistakes made during those manipulations and the harmful side
[quoted text clipped - 6 lines]
>>  The harmful side effects will not disappear over time and will
>> be perpetuated.

Signature

Tony Cooper - Orlando, Florida

Odysseus - 31 Dec 2008 01:12 GMT
In article
<ec9d4a87-21b7-4496-8b19-68691f379a17@g3g2000pre.googlegroups.com>,

> Hello!  Would someone please help me interprete the last sentence of
> the following passage.  I suppose that ***they*** in the last sentence
> refers to ÅgMistakesÅh, not Ågthose manipulations.Åh   I wonder if I am
> right or wrong, and why.

<snip>

> "In contrast, germ-line genetic manipulations alter the reproductive
> cells of the organism. As a consequence, those alterations will be
> passed on to all subsequent generations. Mistakes made during those
> manipulations and harmful side effects that ***they*** cause will not
> disappear with time, but will be perpetuated."

I'd say that "they" must refer to "mistakes" because "manipulations" is
set aside in the adverbial phrase that begins with "during". Paring the
sentence down we get "[The m]istakes made and [the] effects that they
cause will not disappear."

Signature

Odysseus

Lazypierrot - 31 Dec 2008 02:18 GMT
Thanks everyone for your kind comments!

> I'd say that "they" must refer to "mistakes" because "manipulations" is
> set aside in the adverbial phrase that begins with "during". Paring the
[quoted text clipped - 3 lines]
> --
> Odysseus

***they*** as a subject in the relative pronoun phrase "that
***they*** cause" should refer to "Mistakes" rather than
"manipulations" in the adverbial phrase modifying "Mistakes" makes
good sense to me.

LP
 
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